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Authors
Affiliations
1 Dept. of Pharmaceutical Technology, Jadavpur University, Kolkata-700 032, IN
2 Oxford College of Pharmacy, 6/9, 1st Cross, Begur Road, Hongasandra, Bangalore-560 068, IN
3 Krupanidhi College of Pharmacy, #12/1, Chikkabellandur, Carmelram Post, Bangalore-560 035, IN
Source
Journal of Pharmaceutical Research, Vol 9, No 3 (2010), Pagination: 141-147
Abstract
This work aims at designing and evaluating a Extended release dosage form of Diazepam using Alginate- Eudragit RS 30D as the matrix-forming polymer employing the Ionotropic Gelation technique of micropellletization. The product was characterized by physicochemical parameters such as yield, drug entrapment efficiency, particle size, surface topography, granulometric study, loose surface crystal study, drug-excipient compatibility and in vitro release. The controlled release profile was optimized using a factorial design for achieving the correct blend of microparticles that closely matches the target release profile. The study illustrates the utility and advantage of designed experimentation in controlled drug delivery research.
Keywords
Diazepam, Extended Release, Micropellets, Factorial Design, Optimization
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